UPDATE 
  ushop_products 
SET 
  enable_offer = 'E' 
WHERE 
  product_id IN (
    306, 307, 308, 309, 412, 413, 414, 415, 
    420, 421, 422, 423, 424, 425, 426, 427, 
    428, 429
  )

Query time 0.00035

Result

bool(true)